Siofor influence on the process of lipid peroxidation and antioxidant status at patients with metabolic syndrome

摘要

The?purpose?of?the?work?is?to?research?siofor?influence?(metformin)?on?the?activity?of?the?process?of?lipid?peroxidation?and?antioxidant?activity?of?blood?serum?at?patients?with?metabolic?syndroe.?Material?and?Methods?—?62?patients?with?metabolic?syndrome?at?the?age?from?30?till?60?were?examined?and?treated?by?siofor?(1700?mg?per?day)?during?a?year.?The?process?of?lipid?peroxidation?was?studied?due?to?the?level?of?lipid?hydroperoxide?of?blood?serum.?Antioxidant?capacity?was?based?on?the?antioxidant?reaction?in?the?blood?serum?with?definite?number?of?exogenic?hydrogen?dioxid?(mkmole/l)?with?the?method?of?enzyme‐linked?immunosorbent?assay?(ELISA).?Results?—?Intensification?of?process?of?lipid?peroxidation?has?been?observed?at?patients?with?metabolic?syndrome?—?the?level?of?lipid?hydroperoxide?of?blood?serum?has?been?2.9?(1.9,?3.9)?mkM?(presented?as?median?and?interquartile?range),?antioxidant?activity?of?blood?serum?has?been?decreased?—?276.4?(239.0,?379.9)?mkmole/l.?In?12?months?of?siofor?intake?hydroperoxide?level?has?been?decreased?till?1.1?(0.8,?1.9)?mkМ,?but?antioxidant?activity?has?been?increased?and?amounted?320.0?(278.9,?334.3)?mkmole/l.?Conclusion?—?Siofor?has?been?proved?to?be?a?highly?effective?medicine?for?correction?of?process?of?lipid?peroxidation?and?for?improvement?o?antioxidant?activity?of?blood?serum?at?patients?with?metabolic?syndrome.