Preemptive Analgesia with Parecoxib in Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial

摘要

Background: Total hip arthroplasty (THA) is a well-accepted surgical treatment for terminal hipdiseases.Objective: To evaluate the effect of preemptive analgesia with parecoxib in patients undergoingprimary unilateral THA.Study Design: A randomized, double-blind, placebo-controlled study.Setting: This study was conducted at Peking Union Medical College Hospital and Beijing JishuitanHospital in Beijing, China.Methods: A total of 94 patients scheduled for primary unilateral THA in 2 centers (Peking UnionMedical College Hospital and Beijing Jishuitan Hospital) were randomly assigned to receive 40mg parecoxib (n = 48) or 0.9% normal saline solution (n = 46) 30 minutes before incision. Allpatients received standardized intravenous patient-controlled analgesia (PCA) postoperatively.Preoperative baseline data, surgery-related conditions, postoperative Visual Analog Scale (VAS)pain score, cumulative narcotic consumption of PCA, and complications were compared betweenthe parecoxib group and the placebo group.Results: There were no significant differences in postoperative VAS pain score, cumulative narcoticconsumption of PCA, proportion of analgesic remedy, and complications between the 2 groups.Limitations: Only a single dose of parecoxib was used without including a dose-dependentcontrol group.Conclusion: A single dose of parecoxib 30 minutes before incision did not provide effectivepreemptive analgesia for the management of postoperative pain after primary unilateral THA. Thepossible effect of preemptive analgesia with parecoxib needs further investigation.