Comparative Human Factors Evaluation of Two Nasal Naloxone Administration Devices: NARCAN ? Nasal Spray and Naloxone Prefilled Syringe with Nasal Atomizer

摘要

IntroductionOpioid overdose rescue situations are time-critical, high-stress scenarios that frequently require nonmedical first responders or bystanders to intervene and administer naloxone to avoid opioid-induced fatalities. Training nonmedical personnel to respond during such mentally constraining situations presents the human factors challenge of how best to design a safe and effective lay delivery system. This paper comparatively evaluates the ease of use of two nasal naloxone administration products: NARCANsup ? /sup Nasal Spray and a naloxone prefilled syringe with nasal atomizer (PFS-NA). MethodsWe evaluated the use requirements and usability of NARCANsup ? /sup Nasal Spray versus a naloxone PFS-NA using a systems-oriented method. First, we determined the use requirements of different user groups. Next, we focused on constructing a human factors task analysis of both products. Finally, we conducted a comparative risk assessment of the tasks that were different between the two products. ResultsInexperienced users, such as nonmedical first responders and bystanders, are at the highest risk of incorrectly administering naloxone, particularly in high-stress emergency opioid overdose situations. The device Preparation and Medication Delivery tasks most differentiate the use of NARCANsup ? /sup Nasal Spray and a PFS-NA. The level of task complexity and number of steps within those tasks is substantially greater for a PFS-NA than for the NARCANsup ? /sup Nasal Spray. ConclusionsNARCANsup ? /sup Nasal Spray requires fewer steps and is easier to administer than a naloxone PFS-NA. Thus, using NARCANsup ? /sup Nasal Spray should increase the likelihood that nonmedical personnel correctly deliver naloxone in time-critical, high-stress opioid overdose rescue situations. FundingADAPT Pharma, Inc.