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Absence epilepsy - electroclinical features and current advances

机译:失神癫痫-临床特征和最新进展

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The purpose of this article is to provide an overview of the electroclinical features and pathophysiological findings, as well as the neuropsychological characteristics of absence epilepsies. Absence seizures are primary generalized, non-convulsive seizures. The classical clinical manifestations of typical absence seizures are a transient impairment of consciousness (with abrupt onset and offset) accompanied by staring, blinking and various forms of head/limb automatism. Atypical absence attacks are characterized by a milder beginning and end of the attack, more expressed changes in muscular tone, less severe disorders of consciousness, and longer duration compared to typical attacks. EEG findings in absence epilepsies have a characteristic pattern, demonstrating generalized spike and wave complexes that are typically 2.5-4 Hz. Treatment depends on the type of epilepsy, but usually includes valproic acid and ethosuximide. Because of their benign nature and lack of clinical presentation that resembles a€?reala€? epilepsy, absence attacks are often interpreted as daydreaming or simply a lack of attention, and therefore often the first signs of the disease are often not recognized. Conclusion : A better understanding of absence epilepsies is very important in order to develop strategies that will improve these childrena€?s quality of life.
机译:本文的目的是概述缺席癫痫的电临床特征和病理生理结果,以及神经心理学特征。失神性癫痫是原发性全身性非惊厥性癫痫。典型的失神性癫痫发作的经典临床表现是意识的短暂损害(突然发作和偏移),伴有凝视,眨眼和各种形式的头/肢自动症。与典型发作相比,非典型性发作缺乏发作的特点是发作的开始和结束较温和,肌张力变化更明显,意识障碍较轻,持续时间更长。在没有癫痫的情况下,EEG的发现具有特征性模式,表明一般为2.5-4 Hz的广义尖峰和波复合体。治疗方法取决于癫痫的类型,但通常包括丙戊酸和乙巯乙酰亚胺。由于其良性性质和缺乏类似于“ reala”的临床表现,癫痫,失神发作常被解释为做白日梦或只是缺乏注意力,因此,常常没有意识到该病的最初症状。结论:对缺席癫痫的更好的了解对于制定改善这些儿童生活质量的策略非常重要。

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