0120 SUVN-G3031, a Novel, Potent and Selective Histamine H3 Receptor Inverse Agonist for the Treatment of Narcolepsy: Preclinical Characterization

摘要

IntroductionNarcolepsy is a rare long-term brain disorder that causes a person to suddenly fall asleep at inappropriate times. H3R antagonists/ inverse agonists increase histaminergic neurotransmission and offer a therapeutic option for the treatment of narcolepsy. SUVN-G3031 is a potent H3R inverse agonist in the clinical development for the treatment of narcolepsy with or without cataplexy.