The Effect of Diabetes Mellitus Control on Subclinical Inflammation in Type 2 Diabetes Mellitus

摘要

Purposeful: To study the state of subclinical inflammation in patients with type 2 diabetes mellitus. Moreover, to study the relation, if any, between glycemic control and inflammation. Background: Subclinical inflammation and presence of almost all indicators of systemic inflammation are found in type 2 diabetic patients. Such a systemic and subclinical inflammatory process can be characterized by elevated circulating levels of inflammatory markers. Methods: This research included 90 subjects divided into 2 groups; Group A: 70 patients with type 2 diabetes at the time of presentation and Group B: 20 Age and sex matched people as the control group. After providing written informed consent, all patients were clinically examined, had laboratory investiga t ions including; fasting and 2 hours postprandial blood sugar, HbA1c, serum ferritin., high sensitivity C-reactive protein, kidney functions tests, liver function tests, complete blood count and erythrocyte sedimentation rate and antinuclear antibody. Results: Regarding laboratory investigations there was significant difference between the two group regarding revealed that diabetic patients had higher values of; ESR, Hs-CRP and serum frritin. Correlation study revealed significant positive correlation between HbA1c and (Hs-CRP and serum frritin). Summary: Our findings suggest that there is augmented inflammation in T2DM patients manifested by elevated ESR, serum ferrtin and hs-CRP. Also, we found significant positive correlation between HbA1c and (Hs-CRP and serum ferritin). All these finding suggesting a link between inflammation and glycemic control in patient with type 2 diabetes mellitus.