Hepatitis B Virus Infection Serology and the Associated Risk Factors Among Patients With HIV in Shiraz, Iran

摘要

Background:HumanImmunodeficiencyVirus-1(HIV-1)andHepatitisBVirus(HBV)aretransmittedthroughcommonroutes;therefore,simultaneousinfectionwithbothvirusesiscommon.Objectives:ThecurrentstudyaimedtodetermineHBVinfectionserologicalprofileandtheassociatedriskfactorsamongHIVpositiveindividualsinShiraz.PatientsandMethods:Inthiscross-sectionalstudy,186HIVinfectedindividualsabove18yearsold,referringtoShirazVoluntaryCounselingandTestingCenterfrom2010to2011wereenrolled.AllparticipantswereassessedfortheserologicalstatusofHBVinfectionusingHepatitisBsurfaceantigen,HepatitisBsurfaceantibody,HepatitisBcoreantibodylevels,andHBVPolymeraseChainReaction.Results:Atotalof186HIVpositiveindividualseligibleforanalysisincluding164(88.2%)malesand22(11.8%)femaleswereselectedforthestudy.HepatitisBsurfaceantigen(HBsAg),HepatitisBsurfaceantibody(HBsAb)andHepatitisBcoreantibody(HBcAb)weredetectedin66(35.5%),62(41.3%),and39(21%)subjects,respectively.HBVDNAwasdetectedin39subjects(21%).Conclusions:ThecurrentstudyshowedthatlessthanhalfoftheHIVpositiveparticipantshadevidenceofpreviousexposuretoHBV.Also,theriskofchronicHBVwashigherinthesubjectsthanthenormalpopulation.ItissuggestedtoeducateHIVpositiveindividualsregardingpreventionandtransmissionofotherviralinfectionssuchasHBV,HCV,andcompliancewiththeirmedication.