Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

Sharad Sharma; Hang-Ping Yao; Yong-Qing Zhou; Jianwei Zhou; Ruiwen Zhang; Ming-Hai Wang

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Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

机译：mTOR抑制剂AZD8055预防BMS-777607诱导的多倍体/衰老使乳腺癌细胞对细胞毒性化学疗法敏感

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Targeted inhibition of MET/RON signaling by tyrosine kinase inhibitor BMS-777607 for cancer treatment is currently under clinical trials. We have previously shown that BMS-777607 induces chemoresistance invitro by causing polyploidy, which hampers therape

机译：酪氨酸激酶抑制剂BMS-777607对MET / RON信号的靶向抑制目前正在临床试验中。先前我们已经证明BMS-777607通过引起多倍体来诱导体外化学抗药性，从而阻碍了治疗

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《Molecular oncology.》 |2014年第3期|共14页
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Sharad Sharma; Hang-Ping Yao; Yong-Qing Zhou; Jianwei Zhou; Ruiwen Zhang; Ming-Hai Wang;
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中图分类肿瘤学;
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1. Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro [J] . LiuH., ScholzC., ZangC., Anticancer Research: International Journal of Cancer Research and Treatment . 2012,第5p1565a1966期

机译：二甲双胍和mTOR抑制剂依维莫司（RAD001）使乳腺癌细胞对体外化疗药物的细胞毒性作用敏感
2. The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8 [J] . Jia-jie SHI, Si-meng CHEN, Chen-liang GUO, 中国药理学报：英文版 . 2018,第008期

机译：mTOR抑制剂AZD8055通过下调HSPB8克服乳腺癌细胞中的他莫昔芬抗性
3. The mTOR inhibitor RAD001 sensitizes tumor cells to the cytotoxic effect of carboplatin in breast cancer in vitro. [J] . Liu H, Zang C, Schefe JH, Anticancer Research: International Journal of Cancer Research and Treatment . 2011,第9期

机译：mTOR抑制剂RAD001在体外使肿瘤细胞对卡铂对乳腺癌的细胞毒性作用敏感。
4. Phytochemistry Test and Cytotoxic Activity of Macroalgae Eucheuma sp. as a Growth Inhibitor of Breast MCF-7 Cancer Cells [C] . Elvira Lesmana, Ade Arsianti, Trivani Putri, International Symposium of Biomedical Engineering . 2019

机译：植物化学试验及大草原Eucheuma SP的细胞毒性活性。作为乳腺MCF-7癌细胞的生长抑制剂
5. Overexpression of nuclear and mitochondrial-targeted MPG sensitizes breast cancer cells to chemotherapeutic agents and results in an imbalance in DNA repair [D] . Limp-Foster, Melissa M. 2001

机译：核和线粒体靶向的MPG的过表达使乳腺癌细胞对化疗药物敏感并导致DNA修复失衡
6. Prevention of BMS‐777607‐induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics [O] . Sharad Sharma, Hang-Ping Yao, Yong-Qing Zhou, 2014

机译：通过mTOR抑制剂AZD8055预防BMS‐777607引起的多倍体/衰老可使乳腺癌细胞对细胞毒性化学疗法敏感
7. mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib [O] . Elyse K. Hanly, Robert B. Bednarczyk, Neha Y. Tuli, 2015

机译：MTOR抑制剂使甲状腺癌细胞敏化vemurafenib的细胞毒性作用
8. Breaking Cancer Dormancy to Sensitize Dormant Breast Cancer Cells to Cytotoxic Chemotherapy. [R] . Tran, D. 2012

机译：打破癌症休眠，使休眠乳腺癌细胞对细胞毒性化疗敏感。

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

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