Beneficial effects of clopidogrel on glycemic indices and oxidative stress in patients with type 2 diabetes

摘要

Objective of present study is to evaluate the possible role of clopidogrel in improving glycemic indices and oxidative stress in patients with type 2 diabetes. This study was performed on 42 uncontrolled type 2 diabetic patients at the specialized center for Endocrinology and Diabetes, Al-Rasafa Directorate of Health, Baghdad. All of the patients were treated with (glibenclamide 5mg at morning) and randomized into two groups: the first group includes 22 patients treated with clopidogrel tablets (75mg/day) for 2months; the second group includes 20 patients treated with a placebo formula (sodium bicarbonate 200mg/day) for the same period. Treatment with clopidogrel produced significant improvement (P0.05) in the serum levels of these two enzymes. In conclusion the treatment with clopidogrel improved glycemic indices and reduced oxidative stress in patients with type 2 diabetes.