首页> 外文期刊>Science Advances >Oxygen tension–mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia
【24h】

Oxygen tension–mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia

机译:氧张力介导的红细胞膜相互作用调节脑毛细血管充血

获取原文
           

摘要

The tight coupling between cerebral blood flow and neural activity is a key feature of normal brain function and forms the basis of functional hyperemia. The mechanisms coupling neural activity to vascular responses, however, remain elusive despite decades of research. Recent studies have shown that cerebral functional hyperemia begins in capillaries, and red blood cells (RBCs) act as autonomous regulators of brain capillary perfusion. RBCs then respond to local changes of oxygen tension (POsub2/sub) and regulate their capillary velocity. Using ex vivo microfluidics and in vivo two-photon microscopy, we examined RBC capillary velocity as a function of POsub2/sub and showed that deoxygenated hemoglobin and band 3 interactions on RBC membrane are the molecular switch that responds to local POsub2/sub changes and controls RBC capillary velocity. Capillary hyperemia can be controlled by manipulating RBC properties independent of the neurovascular unit, providing an effective strategy to treat or prevent impaired functional hyperemia.
机译:脑血流量和神经活动之间的紧密耦合是正常脑功能的关键特征,并构成功能性充血的基础。尽管进行了数十年的研究,但将神经活动与血管反应耦合的机制仍然难以捉摸。最近的研究表明,脑功能性充血开始于毛细血管,红细胞(RBC)充当脑毛细血管灌注的自主调节器。然后,红细胞对氧张力的局部变化(PO 2 )作出反应并调节其毛细血管速度。使用离体微流体技术和体内双光子显微镜,我们检查了RBC毛细血管速度与PO 2 的关系,并表明RBC膜上的脱氧血红蛋白和带3相互作用是对局部反应做出响应的分子开关。 PO 2 改变并控制RBC毛细管速度。毛细血管充血可以通过独立于神经血管单位操纵RBC特性来控制,从而提供治疗或预防功能性充血受损的有效策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号