Clinical findings and outcomes in patients with pyoderma gangrenosum: A single tertiary centre experience

摘要

Background: Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis which has a great variety of clinical presentation and course. Material and methods: We reviewed the medical records of PG patients who were diagnosed and treated in our department between 2015-2018 years. Results: Our study included 16 patients (10 female, 10 male). Lower extremity was the most common location (81%). Of the 16 patients, 8 had multiple ulcerations at the time of diagnosis. Regarding associated comorbidities, haematological disorders (25%) and seronegative arthritis (25%) were the most frequent. Surgery and trauma were detected in two patients as a triggering factor. Pathergy positivity was documented in 6 patients. First-line immunosuppressive monotherapy was effective in 7 (43%) patients. Mean duration to complete remission was 4.6 months. Conclusions: In our study we present our experience with some unusual aspects. Our series represented male predominance and higher rates of associated haematological disorders. Initial treatment with systemic corticosteroids is likely to be associated with faster response.