Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity

摘要

A series of substituted 1,3,4-oxadiazole derivatives(3a–f)and(6a–f)have been synthesized from diphenylacetic acid hydrazide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, and1H NMR. These targeted compounds have been tested for their antibacterial and antifungal activities compared to ampicillin and griseofulvin as standard drug. Compounds3a, 3e, 3f, 6c, 6d, 6e, and6dexhibited the maximum antibacterial activities while3b, 3c, 3d, 3e, 6a, 6d, and6eexhibited the maximum antifungal activities.