Synthesis and Antimicrobial Activities ofN-(Heteroaryl-substituted)-p-toluenesulphonamides

摘要

A new class ofN-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction ofp-toluenesulphonyl chloride1with appropriate substituted amino pyridines2a–gin acetone furnishedN-(heteroaryl-substituted)-p-toluenesulphonamides3a–g. These derivatives were characterized by IR,1H-, and13C-NMR spectroscopy and were screenedin vitroagainst gram-positive bacteria, gram-negative bacteria, and fungi organisms using agar-diffusion method. Results indicated improved biological activities over reference drugs such as Tetracycline (TCN) and Fluconazole (FLU).