Role of Vaginal Progesterone in Prevention of Preterm Labor in Women with Previous History of One or More Previous Preterm Births

摘要

Objective: >> style="font-family:""> style="font-family:Verdana;">To evaluate whether prophylactic administration of 200 mg vaginal progesterone can reduce the incidence of preterm birth in women with documented history of preterm birth <37 weeks of gestation or not. style="font-family:Verdana;"> Setting: style="font-family:Verdana;">Obstetrics and Gynecology Department, Zagazig University Hospital, Egypt. style="font-family:Verdana;"> Methods:>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">Ninety patients with previous history of preterm birth prior to 37 week presenting with singleton pregnancy between 20>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">->> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">24 weeks were randomly allocated to receive either the progesterone 200>> style="font-family:""> >> style="font-family:""> style="font-family:Verdana;">mg vaginal suppository or no treatment. style="font-family:Verdana;">Results:>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">The incidence of preterm labor before 37 weeks of gestation was significantly lower in the study group than in the control group (22.2 style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">% style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">. style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> 53.3%) especially in earlier gestational ages. While, the mean birth weight was significantly higher in the study group than in control group (2872.67 ± 565.76 gm vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">. style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> 2487.78>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">± 742.40 gm).>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">The neonatal morbidities and mortality associated with preterm labor were significantly lower in the study group than in the control group as shown by lower incidence of neonatal RDS (13.3 style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">% style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> vs style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">.>> style="font-family:""> style="font-family:Verdana;"> 31.1%; style="font-family:Verdana;">P style="font-family:Verdana;"> = 0.043) and lower incidence of the n