EVALUATION THE EFFECT OF THREE HOME-MADE MICRONEEDLE ELECTRODES ARRAY FOR IONTOPHORETIC METHYLENE BLUE DYE AND INSULIN TRANSDERMAL DELIVERY IN DIABETES-INDUCED MICE SKIN

摘要

Diabetic patients are in rapid increase globally. An efficient drug delivery may decrease the disease burden. In the current experimental research design, the effect of three home-made microneedle (MN) electrodes arrays (parallel, triangular and circular) for iontophoretic methylene blue (MB) dye and insulin transdermal delivery was evaluated on diabetes-induced mice. The methods involve a short time (5 s) exposure of high voltage square pulsed (50 V), followed by applying a direct current (DC) up to 0.5 A of 6, 9 and 12 V for 5 minutes on mice skin. The circular micro needle (MN) electrode array showed a relative significant ( p 0.05) higher response that emphasized by the decrease in glucose level of treated groups compared with control, and histomorphometrical analysis for microscopic photo of MB dye expansion in mice skin layers.