An investigation on the chemical stability and a novel strategy for long-term stabilization of diphenylalanine nanostructures in aqueous solution

摘要

Graphical abstract Display Omitted Highlights ? The dissolution rate of FF MTs and MWs was determined by a new HPLC method. ? The dissolution rate of FF MTs is higher than that of FF MWs in aqueous solution. ? Avrami-Erofe’ev kinetic model can describe the dissolution mechanism of the FF nanostructures. ? A novel strategy was developed to prepare chemically stable FF MTs. Abstract The stability of diphenylalanine (FF) microwires and microtubes in phosphate buffer solution was investigated and a novel strategy was developed for their chemical stabilization. This stability investigation was carried out by optical microscopy and by high performance liquid chromatography (HPLC). These microstructures dissolve in the solution depending upon their degree of FF saturation. The dissolution mechanisms of the structures in kinetically limited processes were found by accurately fitting the experimental dissolution data to a theoretical kinetic equation. The dissolution data were well fitted to the particular Avrami-Erofe’ev kinetic expression ( R 2 0.98). These findings suggest that the structures can be stabilized by a decrease in the hydration of the constituent molecules thorough a chemical conformational induced transition upon heat treatment. The stable microtubes were fabricated in a novel three step procedure consisting of the reduction of silver ions in unstable FF microtubes by a citrate reductant, the stabilization by chemical conformational induced transition upon heat treatment, and the consequent oxidation of the reduced silver by a persulfate oxidant. These materials were characterized by electron microscopy and powder X-ray diffraction techniques. The long-term stability of both structures was also confirmed by optical microscopy and HPLC.