SYNTHESIS OF FEW 1,3,4-OXADIAZOLE DERIVATIVES BLENDED WITH DIFFERENT HETEROCYCLES AND THEIR IN-VITRO ANTIBACTERIAL ACTIVITIES

摘要

In the present article, we have described the synthesis of few novel 1,3,4-oxadiazole derivatives (4a-f) blended with quinoline, benzofuran and pyrazole nuclei obtained by the cyclization followed by acetylation of corresponding carbohydrazides (3a-f) with acetic anhydride. Intermediary compounds (3a-f) were obtained by condensation of 5- (benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3- carbaldehydes (2a-f) in the presence of the small amount of acetic acid in ethanol. The structure of synthesized compounds was confirmed through spectral studies like IR, 1HNMR, 13CNMR and Mass spectra’s besides elemental analysis. All the synthesized compounds were assessed for in-vitro antibacterial activities against S. aureus and E. coli, the consequence of assessment was compared with as standard reference drug.