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Influência do corticoide na cicatriza??o do manguito rotador de ratos – Estudo biomecanico

机译:皮质类固醇激素对大鼠肩袖愈合的影响-生物力学研究

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ResumoObjetivo comparar a resistência da cicatriza??o, com rela??o a tens?o máxima, for?a máxima e for?a de ruptura, do tend?o infraespinhal de ratos submetidos a inocula??o de corticoides após a les?o e a reparos experimentais. Métodos foram submetidos 60 ratos Wistar a tenotomia do tend?o infraespinhal e suturados. Previamente à cirurgia foram divididos em grupo controle (C), inoculados com soro, e grupo de estudo (E), inoculados com corticoides sobre o tend?o. Após o reparo os ratos foram sacrificados em grupos de 10 indivíduos do grupo controle e 10 do grupo de estudo em intervalos de uma semana (C1 e E1), três semanas (C3 e E3) e cinco semanas (C5 e E5). Os ratos foram dissecados com a separa??o do tend?o infraespinhal do úmero. As pe?as de estudo foram submetidas a teste de tra??o e avaliadas – tens?o máxima (kgf/cm2), for?a máxima (kgf) e for?a de ruptura (kgf) – e comparando os grupos de estudo com os grupos controle. Resultados dentre os ratos sacrificados com uma semana observamos maior tens?o máxima do grupo {C1} em compara??o com o grupo E1. As variáveis for?a máxima (kgf) e for?a de ruptura (kgf) n?o diferiram estatisticamente entre os grupos pesquisados. Da mesma forma, nos ratos sacrificados com três semanas o grupo {C3} mostrou apenas resistência maior na tens?o máxima em compara??o com o grupo {E3} (p = 0,007). As demais variáveis n?o apresentaram diferen?as. Nos ratos sacrificados com cinco semanas (C5 e E5), nenhum dos parametros estudados apresentou diferen?as estatísticas. Conclus?o a inocula??o com corticoide sobre o manguito rotador levou a diminui??o da resistência a tens?o máxima da cicatriz pós reparo cirúrgico experimental em uma e três semanas em compara??o com os respectivos grupos controle. Os demais parametros n?o tiveram diferen?a entre os grupos de estudo e os grupos controle. AbstractObjective to compare healing strength of the infraspinatus tendon of rats with corticoid inoculation, regarding maximum tension, maximum force and rupture force, after injury and experimental repair. Methods 60 Wistar rats were subjected to tenotomy of the infraspinatus tendon, which was then sutured. Before the surgery, they were divided into a control group (C) inoculated with serum and a study group (S) inoculated with corticoids over the tendon. After repair, the rats were sacrificed in groups of 10 individuals in the control group and 10 in the study group at the times of one week (C1 and S1), three weeks (C3 and S3) and five weeks (C5 and S5). The rats were dissected, separating out the infraspinatus tendon with the humerus. The study specimens were subjected to a traction test, with evaluation of the maximum tension (kgf/cm2), maximum force (kgf) and rupture force (kgf), comparing the study group with the respective control groups. Results among the rats sacrificed one week after the procedure, we observed greater maximum tension in group {C1} than in group S1. The variables of maximum force (kgf) and rupture force did not differ statistically between the groups investigated. In the same way, among the rats sacrificed three weeks after the procedure, group {C3} only showed greater maximum tension than in group {S3} (p = 0.007), and the other variables did not present differences. Among the rats sacrificed five weeks after the procedure (C5 and S5), none of the parameters studied presented statistical differences. Conclusion we concluded that corticoid diminished the resistance to maximum tension in the groups sacrificed one and three weeks after the procedure, in comparison with the respective control groups. The other parameters did not show differences between the study and control groups.
机译:摘要目的比较损伤后接种皮质类固醇激素的大鼠下鼻肌腱的最大张力,最大力和断裂力的愈合阻力。 o和实验性维修。方法60只Wistar大鼠进行腓骨下肌腱切断并缝合。手术前,将其分为对照组(C)和血清组,研究组(E),血清组接种血清,皮质类固醇接种。修复后,每隔一周(C1和E1),三周(C3和E3)和五周(C5和E5)间隔处死大鼠,对照组为10个人,研究组为10个人。通过将肱骨下肌腱与肱骨分离来解剖大鼠。对研究样品进行拉伸测试并进行评估-最大应力(kgf / cm2),最大强度(kgf)和断裂强度(kgf)-并比较研究组与对照组。在一周后处死的大鼠中的结果中,我们观察到 {C1 }组的最大张力高于E1组。最大强度(kgf)和断裂强度(kgf)的变量在调查的两组之间没有统计学差异。同样,在三周处死的大鼠中,与最大{E3 }组相比,最大{C3 }组仅表现出更大的抵抗力(p = 0.007)。其他变量无差异。在五周时处死的大鼠(C5和E5)中,所研究的参数均未显示出统计学差异。结论:与对照组相比,在实验袖套上进行实验性外科修复后,在肩袖上接种皮质类固醇激素导致对疤痕最大张力的抵抗力降低。其他参数在研究组和对照组之间没有差异。摘要目的比较损伤后和实验修复后最大剂量,最大力和断裂力之间的关系,以比较皮质类固醇接种大鼠的睫状肌腱的愈合强度。方法对60只Wistar大鼠行腓肠肌腱切断术,然后缝合。手术前,将它们分为接种血清的对照组(C)和接种肌腱上的皮质类固醇的研究组(S)。修复后,在一周(C1和S1),三周(C3和S3)和五周(C5和S5)的时间处死大鼠,对照组为10个人,研究组为10个人。解剖大鼠,将肱骨下肌腱分开。对研究样本进行牵引力测试,评估最大张力(kgf / cm2),最大力(kgf)和断裂力(kgf),并将研究组与各个对照组进行比较。在手术一周后处死的大鼠中,我们观察到 C1组的最大张力大于S1组。在研究的组之间,最大力(kgf)和断裂力的变量在统计学上没有差异。同样,在手术后三周处死的大鼠中, {C3 }组仅表现出比 {S3 }组更大的最大张力(p = 0.007),其他变量没有差异。在手术后五周处死的大鼠(C5和S5)中,所研究的参数均未显示统计学差异。结论我们得出的结论是,与对照组相比,在术后1周和3周牺牲的组中,皮质类固醇降低了对最大张力的抵抗力。其他参数未显示研究组与对照组之间的差异。

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