The minimal important difference of the pulmonary functional status and dyspnea questionnaire in patients with severe chronic obstructive pulmonary disease

摘要

BackgroundThe modified version of the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-M) is used in patients with COPD to obtain information about their functional status. It consists of 3 components (change in activities, dyspnea and fatigue) ranging from 0 to 100 and has been shown to be responsive following pulmonary rehabilitation (PR). The interpretation of changes in PFSDQ-M score after an intervention is difficult in the absence of the minimal important difference (MID) of the PFSDQ-M. This study aims at investigating the MID of the PFSDQ-M.MethodsWe enrolled 301 patients with COPD (FEV1 42?±?15%pred) that completed the PFSDQ-M before and after a 3-month PR program (?Chronic Respiratory Disease Questionnaire (CRDQ) +16?±?12 points, ?Six-minute walking distance (6MWD) +47?±?89?m, both p?