Dosimetric comparison of helical tomotherapy, VMAT, fixed-field IMRT and 3D-conformal radiotherapy for stage I-II nasal natural killer T-cell lymphoma

摘要

Background The aim of this study was to compare radiotherapy plans for Stage I-II nasal natural killer/T-cell lymphoma (NNKTL) using helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), Fixed-Field intensity-modulated radiotherapy (IMRT), and three-dimensional conformal radiotherapy (3D-CRT). Methods Eight patents with Stage I-II NNKTL treated with IMRT were re-planned for HT, VMAT (two full arcs), and 3D-CRT. The quality of target coverage, the exposure of normal tissue and the efficiency of radiation delivery were analyzed. Results HT showed significant improvement over IMRT in terms of D_98%, cold spot volume and homogeneity index (HI) of planning target volume (PTV). VMAT provided best dose uniformity ( p =?0.000) to PTV, while HT had best dose homogeneity among the four radiotherapy techniques ( p =?0.000) to PTV. VMAT obviously reduced treatment time ( p =?0.010; 0.000) compared to HT and IMRT. Mean dose of left and right optic nerve was significantly reduced by IMRT compared to HT (19.86%, p =?0.000; 21.40%, p =?0.002) and VMAT (8.97%, p =?0.002; 9.35%, p =?0.001), and maximum dose of left lens of VMAT increased over the HT (36.25%, p =?0.043) and IMRT (40.65%, p =?0.001). Conclusion The unexpected results show that both HT and VMAT can achieve higher conformal treatment plans while getting worse organs at risk (OARs) sparing than IMRT for patients with Stage I-II NNKTL. VMAT requires the shortest delivery time, and IMRT delivers the lowest dose to most OARs. The results could provide guidance for selecting proper radiation technologies for different cases.