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首页> 外文期刊>Retrovirology >Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells
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Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells

机译:细胞对HIV-1的免疫力:感染细胞内新定义的逆转录病毒斗争

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摘要

Studies of the human immunodeficiency virus type 1 (HIV-1) continue to enrich eukaryotic biology and immunology. Recent advances have defined factors that function after viral entry and prevent the replication of proviruses in the infected cell. Some of these attack directly viral structures whereas others edit viral genetic material during reverse transcription. Together, they provide strong and immediate intracellular immunity against incoming pathogens. These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome.
机译:对人类1型免疫缺陷病毒(HIV-1)的研究继续丰富了真核生物和免疫学。最近的进展已经定义了在病毒进入后起作用并阻止原病毒在感染细胞中复制的因素。其中一些直接攻击病毒结构,而其他一些则在逆转录过程中编辑病毒遗传物质。它们共同提供了针对传入病原体的强大而即时的细胞内免疫力。这些过程也为基本的细胞机制提供了诱人的一瞥,这些机制可能会限制流动遗传元件的移动并保护基因组。

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