Synthesis and Crystal structure studies of Diethyl-(6-chloro-2-carbazolyl) Methyl malonate an intermediate in the synthesis of Anti-inflammatory drug Carprofen

摘要

Diethyl-(6-chloro-2-carbazolyl)methyl malonate, an intermediate in the synthesis of anti-inflammatory drug Carprofen and number of biologically active heterocycles, was synthesized and X-ray studies have been performed. The crystal structure analysis shows the title compound crystallizes in triclinic class under the space group P-1 with cell parameters, a = 9.3408(11) -A, b = 10.4853(12) -A, c = 11.1601(13) -A α= 113.623(6), β= 105.130(6), γ= 93.040(6) and Z=2. The molecule exhibits N-H-O type intermolecular hydrogen bond.