Toxicity Study of Korean Ginseng Herbal medicine

摘要

The toxicity studies of Korean ginseng capsules were evaluated in mice through examination of possible biochemical, hematological and histopathological changes. Acute, sub-acute and chronic toxicity studies were undertaken by treating mice with a single dose of 300 mg kg-1 body weight for acute, 100 mg kg-1 body weight administered orally each other day for 7 days for sub-acute and an oral dose of 20 mg kg-1 body weight of the drug daily for 90 days for chronic toxicity studies. In acute, sub-acute and chronic treated mice, biochemical studies revealed a significant decrease in the blood glucose level in all treated animals. Hematological studies revealed an increase in RBC and hemoglobin contents in the treated male group as compared to the control. Absent of signs of visceral toxicity and histopathology result confirmed that all the studied organs were normal compared to the control.