AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells

摘要

BCR-ABL1 fusion tyrosine kinase transforms hematopoietic stemcells and cause chronic myeloid leukemia in chronic phase(CML-CP), which is a stem cell (leukemia stem cell = LSC)-derivedbut progenitor (leukemia progenitor cell = LPC)-driven disease.1BCR-ABL1 kinase is leukemogenic only when expressed in a HSCwith self-renewal capacity, thereby inducing LSC. LSCs arecapable of generating large numbers of LPCs: leukemia commonmyeloid (LCMPs) and leukemia granulocyte/macrophage.