Abstract：Objective To explore the clinical efficacy of high-concentration oxygen therapy combined with recombinant human epidermal growth factor(rhEGF)gel in treatment of neonates with diaper dermatitis and relative nursing interventions. Methods 〓Totally 60 neonates with diaper dermatitis were randomly divided into observation group and control group, with 30 cases in each group. Both groups received routine nursing care. Those in the control group received high-concentration oxygen therapy combined with tannic acid ointment while those in the observation group were given high-concentration oxygen therapy combined with rhEGF gel. The overall response rate(RR)of treatment, wound healing time and Neonatal Infant Pain Scale(NIPS)scores before and after treatment were assessed and compared between two groups. Results 〓The overall RR was 96.67%(29/30)in observation group, higher than the 76.67%(23/30)of the control group(P0.05). NIPS score was decreased in both groups after treatment, and was decreased more significantly in observation group than that in control group(P0.05). The wound healing time was(4.59±2.37)d in observation group, shorter than the(7.98±3.05)d in control group(P0.05). Conclusion 〓Application of high-concentration oxygen therapy combined with rhEGF gel is effective in the treatment of neonates with diaper dermatitis, as shortening wound healing time and reducing the pain degree.
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