SAT-143 MILD HYPERCAPNIA DURING MAJOR SURGERY, A POSSIBLE STRATEGY TO PREVENT RENAL MEDULLARY HYPOXIA AND THE DEVELOPMENT ACUTE KIDNEY INJURY

摘要

Pan-cyclophilin inhibition prevented anticipated IRI- induced acute renal failure by suppressing tubular cell death and inflammation. Our data suggest that CypA promotes leukocyte infil- tration and inflammation leading to acute kidney injury following renal IRI, whilst CypD specifically contributes to cell death from the ischaemic/hypoxic insult.