N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency: (Recours a la N-acetylcysteine pour prevenir une atteinte renale aigue chez les patients de chirurgie cardiaque souffrant

摘要

PURPOSE: N-acetylcysteine may prevent acute kidney injury after cardiac surgery. To determine if N-acetylcysteine warrants definitive evaluation in a large multicentre trial, we evaluated its effects on a surrogate outcome, estimated glomerular filtration rate (eGFR), in a randomized trial. METHODS: One-hundred-seventy-seven cardiac surgery patients with moderate pre-existing renal insufficiency (eGFR