Comparison of the Effects of Total Intravenous Anesthesia and Intravenous Inhalational Anesthesia on Brain Metabolism during Surgery

摘要

To compare the effects on the brain metabolism of propofol-remifentanil total intravenous anesthesia and desflurane-remifentanil intravenous inhalational anesthesia in neurosurgery. Methods: Thirty-four neurosurgical patients with intracranial space-occupying surgery were randomly divided into two groups: Group A was conducted with the propofol-remifentanil total intravenous anesthesia and Group B with desflurane-remifentanil intravenous inhalational anesthesia. The patients were monitored for the brain metabolism prior to anesthesia, 1 hour after surgery, 2 hours after surgery, and half an hour after surgery. Results: The cerebral venous oxygen saturation, jugular bulb oxygen partial pressure, jugular vein oxygen content, and arterial oxygen content of the patients in group B were significantly higher than that of group A (P0.001); arterial-jugular oxygen content difference and brain oxygen uptake rate of group B were lower than that in group A. Conclusions: (1) Both anesthesia methods can reduce the cerebral oxygen consumption and brain oxygen uptake, and thus reduce the cerebral oxygen metabolism.