Neuroprotective effects of willed-movement therapy in a rat model of cerebral ischemia/reperfusion

摘要

The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement (climbing a ladder or wall in a box) when induced by food and water. Results revealed that Longa scores of neurological deficits significantly decreased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43.