Antihyperlipidemic Activity of Ethanolic Extract of Celery Leaves on Rats Rattus norvegicus

摘要

India has about 45000 plant species; while medicinal properties have been assigned to severalthousand. Apium graveolens (Celery) belonging to family Apiaceae, used as a decorative herb in Indiain general and more particular in Punjab and Uttar Pradesh. Celery roots, leaves, stem, oils and seedsare used for the therapeutic purpose in treating and preventing many diseases. In the present studythe effect of celery on cholesterol induced rats was studied. Ethanolic extract of celery leaves wasorally administered by post treatment at the dose level of 500mg/kg of body weight for 7 th , 14 th , 28 th and56 th days respectively. Administration of cholesterol induced rats resulted in increased total cholesterol,triglycerides, LDL, VLDL and decreased the HDL cholesterol. Administration of celery extract resultedin HDL cholesterol increase and decrease in the total cholesterol, triglycerides, LDL and VLDL induration dependent manner. The above finding proved that 56th day treatment of ethanolic extract ofcelery was found to have more protective effect on lipid profiles in cholesterol induced rats. Theresults of the above studies are discussed in the light of recent literature.