DOSE DEPENDENT ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF MENTHA ARVENSIS LEAVES IN TRITON AND HIGH CHOLESTEROL DIET INDUCED RATS

摘要

A study was undertaken to evaluate antihyperlipidemic activity of ethanolic extract of leaves of Mentha arvensis in Triton and high cholesterol diet induced hyperlipidemic male albino Wstar rats. Acute hyper-lipidemia was induced by administration of Triton WR-1339 (100 mg / kg i.v.) to the male albino Wstar rats. In chronic models; the animals were fed with high cholesterol diet for a period of 10 days. EEMA leaves at a dose of 200 and 400 mg/kg of body weight were administered at a single dose per day to the hyperlipidemic induced rats for a period of 14 days. In hyperlipidemic rats there is significant increase in TC, TG, LDL, VLDL level and significant decrease in HDL level, but after post treatment with EEMA, there was a significant decrease in TC, TG, LDL, VLDL and increase in HDL level. Post treatment with EEMA leaves lowered levels of total protein and triglycerides. The human body is complex machinery and various organ and organ system contribute for maintaining the homeostasis. Any undesirable change occuring will disturb the balance, resulting in a diseased state. The lung and other tissues contain polyunsatu rated fatty acids (PUFAs). PUFA is the main component of membrane lipids and is susceptible to peroxidation as a result of oxidative stress leading to loss of functional integrity of the cell membranes. Complication in hyperlipidemia is due to the changes in the level of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and high density lipoprotein levels (HDL). The same way, the change in the level of lipids will lead to many complications1, but lipids are naturally occurring molecules, which are the main component of the cell membrane. They act as blood transporter and their main function is energy storage.