HYPOADIPONECTINEMIA AND DYSLIPIDEMIA IN RELATION TO GLYCEMIC STATUS IN TYPE 2 DIABETES AND CORONARY HEART DISEASE

摘要

OBJECTIVE: to study the relationship of adiponectin level with lipidprofile and glycemic control in type 2 diabetic subjects with and withoutcoronary heart disease (CHD).METHODOLOGY: This cross-sectional/ analytical study consisted ofthree groups. Group A consisted of 60 healthy subjects, group B consisted?of 60 type 2 diabetic subjects and group C consisted of 60 type2 diabetic subjects with coronary heart disease. The study participantswere analyzed for serum adiponectin level, triglycerides (TG), totalcholesterol (TC), high density lipoprotein cholesterol (HDL-C), lowdensity lipoprotein cholesterol (LDL-C), very low density lipoproteincholesterol (VLDL-C), fasting blood glucose (FBG) and glycosylatedhemoglobin (HbA1c).RESULTS: Significantly high adiponectin level was observed in femalesubjects as compared to male subjects. Type 2 diabetic subjects withand without coronary heart disease presented with significantly higherFBG, HbA1c, TC and TG (p value 0.05) and significantly lower levelsof serum adiponectin and HDL-C (p value 0.001). Adiponectin levelshowed significant positive association with HDL-C in control group(female: r 0.988; p=0.01, male: r 0.948; p=0.01), type 2 diabeticgroup (female: r 0.908; p=0.01, male: r 0.860; p=0.01) and type 2diabetic group having coronary heart disease (female: 0.775; p=0.01,male: 0.650; p=0.01). Significant (p value 0.01) negative associationof adiponectin was observed with TG, FBG and HbA1c in type 2 diabeticsubjects with and without coronary heart disease.CONCLUSION: Hypoadiponectinemia in type 2 diabetic subjects withand without coronary heart disease is related with un-controlled glycemicstatus and dyslipidemia.