N 1 -(5-Fluoro-2,4-dinitrophenyl)- N 2 -phenyl-4-(trifluoromethyl)benzene-1,2-diamine

摘要

Treating 1,5-difluoro-2,4-dinitrobenzene ( 1 ) with N 1 -phenyl-5-(trifluoromethyl)benzene-1,2-diamine ( 4 ) and N , N -diisopropylethylamine in EtOH at ca . 0 ???°C for 4 h affords a mixture of N 1 -(5-ethoxy-2,4-dinitrophenyl)- N 2 -phenyl-4-(trifluoromethyl)benzene-1,2-diamine ( 5 ) (38%) and N 1 -(5-fluoro-2,4-dinitrophenyl)- N 2 -phenyl-4-(trifluoromethyl)benzene-1,2-diamine ( 6 ) (51%) that can be separated by chromatography. Repeating the reaction in dichloromethane led to the sole formation of N 1 -(5-fluoro-2,4-dinitrophenyl)- N 2 -phenyl-4-(trifluoromethyl)benzene-1,2-diamine ( 6 ) in 96% yield.