, where R=H, Br, Cl, F, CH3, includes a nucleophilic substitution of the chlorine atom in the 4-nitro-2-(trifluoromethyl)chlorobenzene when interacting with aniline or its corresponding derivative in solvent medium for 2.5 hours at 80°C and molar ratio of 2-nitro-4-(trifluoromethyl)chlorobenzene : 4-R-aniline = 2:1 and recovery of the resulting 2-nitro-N-[2-nitro-4-(trifluoromethyl)phenyl]-N-(4-(R)-phenyl)-4-(trifluoromethyl)aniline. Here, nucleophilic substitution is carried out by ultrasound in DMSO as the organic solvent, in the presence of tributylamine. Recovery of 2-itro-N-[2-nitro-4-(trifluoromethyl)phenyl]-N-(4-(R)-phenyl)-4-(trifluoromethyl)anilines is performed in a mixture of alcohol and 9% hydrochloric acid in volumetric ratio of 1:1, using electric current in a diaphragm cell in galvano-static mode in the presence of TiCl3, taken in the molar ratio of catalyst-carrier: dinitrosubstrate of 0.05:1, at a temperature of 40°C on lead cathode, while a passing a charge 12 F for 0.6 h through electrolytic cell, at current density of 9.45 A/dm2, 10% solution of sulfuric acid is used as the anolyte, platinum is used as the anode. The desired product is isolated.;EFFECT: method allows to obtain products with a high yield in a shorter time, carry out a nucleophilic substitution reaction in homogeneous conditions and is more economical sue to elimination of expensive agents and reduced amount of harmful waste.;10 ex"/>
公开/公告号RU2645922C2
专利类型
公开/公告日2018-03-01
原文格式PDF
申请/专利号RU20160126292
发明设计人 BEGUNOV ROMAN SERGEEVICH (RU);VALYAEVA ASYA NIKOLAEVNA (RU);BASHKIROVA ALEKSANDRA ALEKSANDROVNA (RU);BUZINA VALERIYA ANDREEVNA (RU);PIROGOVA SVETLANA ALEKSANDROVNA (RU);
申请日2016-06-29
分类号C07C211/56;C07C209/36;C07C209/10;C25B3/04;
国家 RU
入库时间 2022-08-21 12:35:45