Intraperitoneal Bupivacaine-Ketorolac forPostoperative Pain Control after LaparoscopicColorectal Surgery: A Double-blindRandomized Controlled Trial

摘要

Background: the study aimed to evaluate the antinociceptive effect of intraperitoneal ketorolac combined with bupivacaine in patients undergoing laparoscopic colectomy. Methods: this prospective randomized double-blind controlled trial included 60 adults scheduled for laparoscopic colectomy randomized into one of two groups according to the analgesic instilled intraperitoneally at the end of surgery. group B (n = 30) received 50 ml of intraperitoneal (Ip) bupivacaine 0.25% + 5 ml of normal saline. group KB (n=30) received 50 ml of intraperitoneal bupivacaine 0.25% + 30 mg ketorolac in 5 ml of normal saline. postoperative pain intensity was measured by visual analogue scale (VAS) score. The time to the first request of analgesia and total morphine consumption were recorded in addition to ponv score. Results: During the whole postoperative period, compared to group B, the vas score was significantly lower (p < 0.001), time to first request of analgesia was significantly longer (p < 0.001) and total morphine consumption was significantly lower in KB group (p < 0.001). Postoperative nausea and vomiting score was significantly higher in Group B (p = 0.001). Conclusion: Intraperitoneal instillation of a combination of bupivacaine 0.25% and ketorolac is a safe and effective option for postoperative analgesic following laparoscopic colectomy in cases colon cancer.