Value of [18F]FDG-PET/CT and CA125, serum levels and kinetic parameters, in early detection of ovarian cancer recurrence: Influence of histological subtypes and tumor stages

摘要

To assess the diagnostic accuracy of CA125 , its kinetic values and positron emission tomography/computed tomography with 2-deoxy-2-[^{18F]fluoro-D-glucose ([18F]FDG-PET/CT), in relation with tumor characteristics for suspected recurrence of ovarian cancer. To evaluate the performance of CA125 -related parameters as a selection criteria to perform a [18F]FDG-PET/CT. A retrospective analysis of 69 [18F]FDG-PET/CT for suspected recurrence of ovarian cancer was performed. All patients had 2 measurements of CA125 , before PET/CT, to calculate kinetic values, as CA125vel (CA125vel = [CA125a ? CA125b]/time) and CA125dt (CA125dt = [log₂ × time]/[logCA125a ? CA125b]). Maximum standard uptake value (SUVmax) was calculated. The diagnostic accuracy was calculated for all the variables and the optimal cut-off value of each of them by the receiver-operating characteristics (ROC) analysis. All the tests were compared with tumor characteristics and clinical-radiological evolution during follow-up of at least 6 months. Fifty-five cases were diagnosed of recurrence (11 with CA125 18F]FDG-PET/CT is more accurate than the parameters obtained from the CA125 to detect early recurrence. CA125vel is the most suitable parameter, mainly in HGSC. Levels of CA125vel ≥ 4.49 U/mL per mo facilitate earlier detection by the execution of a [18F]FDG-PET/CT. The calculation of these parameters is independent of tumor stage at diagnosis.}