MICROWAVE ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME N-BENZYLIDENEANILINE HALOGEN DERIVATIVES

摘要

In this study a series of Schiff base N- Benzylideneaniline halogen derivatives 3 (a-i) were synthesized by microwave-irradiation method the 4-fluoroaniline (2) was condensed with various aromatic aldehydes 1 (a-i) to give Schiff base. The present work involves condensation of various benzaldehyde with aromatic amine in under microwave irradiation. The microwave irradiation method offers advantages such as reduction of reaction time, increase in conversion, reduced wastes and good quality. The chemical structure of the compound was characterized using Mass Spectrometry, 1H NMR and ~(13)C NMR techniques. The prepared compounds were tested for their in vitro antibacterial activity. The agar well diffusion assay method was used for the assessment of in vitro antibacterial activity compounds against Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 15442), Staphylococcus aureus (ATCC 6538) and Bacillus subtilis (ATCC 6633).