Altered Expression Pattern of CD55 and CD59 on Red Blood Cells in Anemia of Chronic Kidney Disease

摘要

Objective: The aim of this study was to investigate the expression pattern of CD55 and CD59 on red blood cells (RBCs) in anemic chronic kidney disease (CKD) patients, and factors that might influence their expression. Subjects and Methods: Nighty-one adult anemic CKD patients and 80 healthy controls (HCs) were enrolled. Anemic CKD patients were divided into 3 subgroups based on receiving erythropoietin and renal replacement therapies. Flow cytometric analysis of CD55 and CD59 expression was performed on RBCs from blood samples obtained from CKD patients and HCs. Results: CD59 deficiency was significantly higher among CKD patients than HCs ( n = 68, 74.7%, vs. n = 13, 16.3%, respectively; p p p p . 04 and p r = -0.37, p r = -0.22, p p = 0.001), and a significant difference was present in the MFI of CD55 and CD59 expression among the 3 subgroups ( p = 0.04 and p = 0.03, respectively). Conclusion: The expression pattern of CD55 and CD59 on RBCs is altered in anemic CKD patients, which could play a role in the pathogenesis of anemia in CKD.