Influence of congenital predisposition upon the development of allergic diseases in infancy

摘要

The study included 73 randomly selected children who were observed during the first year of life. In 24.5% of them, the symptoms of a probable allergic disease, mainly eczema and recurrent or chronic wheezy bronchitis, were found. The majority of all infants were males. Positive immediate family history was established in 44.5% of all allergic infants and the level of cord blood IgE, exceeding 0.5 kU/l were detected in 55.5% of them. Both these parameters were assumed as symptoms of congenital predisposition to allergic diseases in the future. Such predisposition was manifested by 72.2% of infants who showed the symptoms of allergic diseases in the first year of life, and in 30.9% of infants without any symptoms of allergy. Cord blood IgE level test had a greater sensitivity, specificity and efficiency than positive immediate family history as a method of allergy prediction in infants.key words: allergy, infants, cord blood immunoglobulin E