A change of IL-2 and IL-4 production in patients withHelicobactor pyloriinfection

摘要

Helicobactor pyloriis the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism inH. pyloriassociated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or withoutH. pyloriinfection.H. pylorican stimulate IL-2 and IL-4 production from PBL inH. pylorinegative as well asH. pyloripositive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, <0.001)inH. pylorinegative individuals than that inH. pyloriinfected patients. Increased IL-4 levels from PBL inH. pyloriinfected patients were found in the presence ofH. pylori(p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed inH. pyloriinfected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed inH. pyloriinfected patients, which may be responsible forH. pylorichronic infection.