Effect of insulin therapy and obesity on colon adenoma and advanced adenoma among DM II population

摘要

Background: Insulin is a debatable risk factor for colon adenoma (Ad) among type II Diabetes Mellitus (DM II) patients. Obesity is an important confounding variable. Methods: The study involved chart review of DM II patients undergoing screening colonoscopy. Study population was divided into obese (BMI=>30) and non-obese (BMI<30) groups which were further divided into insulin and non-insulin subgroup. Colonoscopy and pathology reports were used to calculate Ad detection rate (ADR) and AAd detection rate (AADR). Results: 538 subjects satisfied the inclusion and exclusion criteria. The study population composed of 52.8% obese and 47.2% non-obese subjects. Obese group had 28.9% insulin and 71.1% non-insulin subjects. Non-obese group composed of 29.9% insulin and 70.1% non-insulin subjects. ADR for non-obese insulin and non-insulin subgroup was 31.6% and 37.1% respectively. AADR for non-obese insulin and non-insulin subgroup was 13.2% and 11.2% respectively. ADR for obese insulin and non-insulin subgroup was 41.5% and 34.2% respectively. AADR for obese insulin and non-insulin subgroup was 15.9% and 16.3% respectively. Summary: Insulin exposure lacked statistically significant association with ADR or AADR among obese and non-obese DM II subjects.