Effect of Short-Term Standard Therapeutic Regimens on Neuropeptide Y and Adipose Tissue Hormones in Overweight Insulinresistant Women with Polycystic Ovary Syndrome

摘要

Effect of Short-Term Standard Therapeutic Regimens on Neuropeptide Y and Adipose Tissue Hormones in Overweight Insulinresistant Women with Polycystic Ovary SyndromeAim: The study was aimed at elucidating the influence of a 3-month treatment with routine therapeutic regimens - oral hormonal contraceptives (OHC) with antiandrogenic activity (a standard combination of ethynil estradiol 35 μg plus cyproterone acetate 2 mg) in combination with insulin sensitizing agents - metformin (Group I) and rosiglitazone (Group II) on adipose tissue hormones and hypothalamic neuropeptide Y (NPY) in women with polycystic ovary syndrome.Patients and methods: The study included 66 overweight insulin resistant women with PCOS according to the recent ESHRE-ASRM criteria randomized into 2 age-matched therapeutic groups.Results: Significant decrease of leptin (P < 0.01; P = 0.001, resp.), resistin (P < 0.01; P < 0.01, resp.), tumour necrosis factor α (TNFα) (P = 0.001; P < 0.001, resp.), and NPY (P < 0.05; P < 0.001, resp.) was observed in both groups after treatment. These findings were in parallel with a significant decrease in the anthropometric parameters of body weight in the metformin group only. No significant changes in hormonal characteristics of the groups were found except for a significant decrease in androstenedione and DHEA-S (P < 0.05) in the metformin group and in 17-OH-progesterone (P < 0.05) in the rosiglitazone group. HDL-cholesterol rose and diastolic blood pressure fell significantly (P < 0.05) in the metformin group.Conclusion: Our data suggest beneficial effects of the treatment on potential cardiovascular risk in insulin resistant PCOS women.