Is Weekly Supplementation of Vitamin D Favorable for Treatment of Osteoporosis in Postmenopausal Women?

摘要

OBJECTIVE: The present study aims to determine whether once weekly supplementation of vitamin D?and alendronate is efficient and safe for treatment of postmenopausal osteoporosis. STUDY DESIGN: Group I (42 women with postmenopausal osteoporosis) received daily supplementation?of calcium (1000 mg) and vitamin D (880 IU) while group II (42 women with postmenopausal osteoporosis)?had weekly supplementation of vitamin D (2800 IU) along with weekly treatment of alendronate?(70 mg). RESULTS: Group I had significantly lower lumbar spine T-scores before and after treatment. Post-treatment?lumbar spine T-scores and femur neck T-scores were significantly higher with respect to pre-treatment?scores in both study groups. The alterations in lumbar spine and femur neck T-scores were statistically?similar in both group I and group II. CONCLUSION: Once weekly administration of vitamin D and alendronate is an effective and safe option?of treatment for women who cannot take calcium supplements for postmenopausal osteoporosis.