Nuchal Translucency Measurement Did Not Significantly Predict Trisomy Cases in Tertiary Referral Center

摘要

OBJECTIVE: We sought to determine the value of well defined screening method in predicting trisomy?cases in our institution. STUDY DESIGN: Totally 300 amniocentesis cases were screened from prospectively collected database.?Subjects were referred to amniocentesis according to the sequential results of first and second?trimester screening tests. Each case had nuchal translucency measurement between 11th to 14th weeks?of gestation. All values of NT measurement were analyzed to predict trisomy cases. RESUlTS:There were 7 trisomy cases , non of the screening methods significantly predicted trisomy?cases (p0.05) rather than the simply age (Area under curve 0.724, p=0.043). Mean NT did not differ?between groups with normal and abnormal chromosomes(p0.05). CONClUSION: This data led us to conclude that in our country there is still need for more accurate and?standardized method to predict abnormal cases with higher sensitivity and specificiy to decrease invasive?procedures.