Association Between Maternal Serum Total Oxidant Status Total Antioxidant Status and Preterm Labor: A Prospective - Controlled Clinical Study

摘要

OBJECTIVE: To measure the levels of individual antioxidant components of pregnants with preterm?labor to evaluate their total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress?index (OSI). STUDY DESIGN: Prospectively-controlled 31 pregnants with a diagnosis of preterm labor (group Ι) and?32 controls (group ΙΙ) were evaluated for demographic data, general and obstetrical physical examination,?obstetrical sonography, and routine laboratory tests. TAS, TOS and OSI levels were also measured. RESULTS: There was no difference in terms of demographic data, ultrasound and routine laboratory parameters,?total oxidant levels, total antioxidant capacity and oxidative stress index between the two?groups (p=0.621, p=0.706 and p=0.450, respectively). CONCLUSIONS: Improper balance between TAS and TOS may not be a major issue in the pathogenesis?of preterm labor in which infection does not precede. ‘Screening or prediction of preterm labor‘?needs new trials with large populations, particularly concerning enviromental and dietary features of the?population.