A Lipoprotein Lipase–Promoting Agent, NO-1886, Improves Glucose and Lipid Metabolism in High Fat, High Sucrose–Fed New Zealand White Rabbits

摘要

The synthetic compound NO-1886 is a lipoproteinlipase activator that lowers plasma triglycerides andelevates high-density lipoprotein cholesterol (HDL-C).Recently, the authors found that NO-1886 also had an actionof reducing plasma glucose in high-fat/high-sucrosediet–induced diabetic rabbits. In the current study, weinvestigated the effects of NO-1886 on insulin resistanceandβ-cell function in rabbits. Our results showed thathigh-fat/high-sucrose feeding increased plasma triglyceride,free fatty acid (FFA), and glucose levels and decreasedHDL-C level. This diet also induced insulin resistanceand impairment of acute insulin response toglucose loading. Supplementing 1% NO-1886 into thehigh-fat/high-sucrose diet resulted in decreased plasmatriglyceride, FFA, and glucose levels and increased HDL-Clevel. The authors also found a clear increased glucoseclearance and a protected acute insulin responseto intravenous glucose loading by NO-1886 supplementation.These data suggest that NO-1886 suppressesthe elevation of blood glucose in rabbits induced by feeding a high-fat/high-sucrose diet, probably throughcontrolling lipid metabolism and improving insulinresistance.