Clinical evaluation of sublingual administration of dust mite drops in the treatment of allergic asthma and allergic rhinitis of children

摘要

OBJECTIVE: This study focuses on evaluating the clinical effects of sublingual dust mite drops for the treatment of allergic asthma in children. PATIENTS AND METHODS: 156 pediatric patients with allergic rhinitis and asthma were randomly divided into control and observation groups (78 cases each). For the control group the standard global initiative for asthma (GINA) asthma control scheme was adopted; meanwhile, the observation group patients received the standard GINA combined with sublingual administration of dust mite drops, once per day, gradually increasing the dose to reach a high maintenance level. After six months the sublingual drops were stopped and then the effects of the treatments on both groups of patients were compared. RESULTS: The symptoms of asthma and rhinitis in the daytime and nighttime for both groups decreased gradually with time. However, the observation group’s outcome at the 6th, 12th and 24th month were significantly better than those of the control group ( p 1 and PEF values of the two groups increased gradually, but those of the observation group improved more obviously ( p 0.05). But at the 24th month, the observation group had significantly higher rates of complete and good control ( p 0.05); however, the levels of IL-2 increased gradually and improved more in the observation group ( p < 0.05). CONCLUSIONS: The results of our study support the notion that sublingual administration of dust mite drops to treat allergic rhinitis and asthma can improve clinical symptoms, increase the efficiency rate and increase the serum IL-2 level, and does not cause an increase in adverse reactions or IgE levels in treated children.