'compound, use of this or a pharmacologically acceptable salt, ester or other derivative thereof, medication, preventive or therapeutic agents for asthma and / or bronchitis, for rhinitis, for allergic disease, and for urinary incontinence, and, prevention processes or treatment of asthma and / or bronchitis, rhinitis, allergic disease, and urinary incontinence. '

摘要

"COMPOUND, USE OF THIS OR A PHARMACOLOGICALLY ACCEPTABLE SALT, IS EITHER OR OTHER DERIVATIVE FROM THE SAME, MEDICINAL PRODUCTS, PREVENTIVE OR THERAPEUTIC AGENTS FOR ASTHMA AND / OR BRONCHITIS, FOR RHINITIS, FOR ALLERGIC DISEASE, AND FOR URINARY PROCEDURE, OR URINARY PROCEDURE, AND URINARY PROCEDURE, OR URINARY PROCEDURE, OR URINARY PROCEDURE, OR URINARY PROCEDURE, OR URINARY PROCEDURE, OR URINARY PROCEDURE, OR URINARY PROTECTION, OR URINARY PROCEDURE, AND URINARY PROCEDURE, OR URINARY PROTECTION, OR URINARY PROCEDURE. TREATMENT OF ASTHMA AND / OR BRONCHITIS, RHINITIS, ALLERGIC DISEASE, AND URINARY INCONTINENCE "[Object] Provide compounds having selective antagonistic activity against NK ~ 2 ~ receptor. [Medium for resolving the object] A compound of formula (I), a pharmaceutically acceptable salt or derivative thereof: {R¹: optionally substituted cycloalkyl, or optionally substituted heterocyclic group; R² optionally substituted aryl, or optionally substituted heteroaryl; A: methylene, carbonyl or sulfonyl; B: single bond, alkylene or alkenylene; D: oxygen atom or sulfur atom; G: alkylene or alkenylene; L - -N (R³) - or -C (R ^ 4 ^) (R ^ 5 ^) -, [R³: optionally substituted aryl or optionally substituted heteroaryl; R 4: H, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl or optionally substituted saturated heterocyclic group; R ^ 5 ^ alkyl optionally substituted with amino, amino, optionally substituted acylamino, OH, optionally substituted hydroxyalkyl, alkoxy or -CO-R ^ 6 ^ (R ^ 6 ^: alkyl, alkoxy or amine residue); or R ^ 4 ^ together with R ^ 5 ^: cycloalkane ring, cycloalkene ring, saturated heterocyclic ring]; R 7: alkyl; Z: two hydrogen atoms or one oxygen atom; n: 0, 1 or 2}.