A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48?h

摘要

BackgroundAn animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy.MethodsA standardized polytrauma including lung contusion, liver laceration and lower leg fracture was applied in 25 pigs. They underwent controlled haemorrhage either with a blood volume loss of 45?% and a median arterial pressure (MAP) <30?mmHg/90?min (group L, n?=?15) or a 50?% blood loss of and an MAP <25?mmHg/120?min (group H, n?=?10). Five non-traumatized pigs served as a control (group C). Subsequently, intensive care treatment was given for an observational period of 48?h.ResultsBoth trauma groups showed signs of shock and organ injury (heart rate, MAP and lactate). The frequency of cardiopulmonary resuscitation (CPR) and lung injury was directly related to the severityof the haemorrhagic shock (CPR—group L: 4 of 15 pigs, group H: 4 of 10 pigs; Respiratory failure—group L: 3 of 13, group H: 3 of 9. There was no difference in mortality between trauma groups.ConclusionThe present data suggest that our model reflects the mortality and organ failure of polytrauma in humans during shock and the intensive care period. This suggests that the experimental protocol could be useful for the assessment of therapeutic approaches during the post-traumatic period.