Synthesis of Azetidinone Derivatives of 2-Amino-5-Nitrothiazole and their Medicinal Importance

摘要

New series of N-[3-(2-amino-5-nitrothiazolyl)-propyl]-4-(substitutedphenyl)-3-chloro-2- oxo-1-azetidine-carboxamide, compounds 4(a-j) have been synthesized and characterized by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the synthesized compounds 4(a-j) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against M. tuberculosis. Anti-inflammatory activity was in vivo screened against albino rats. Some compounds of the series showed good activities.